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Menthol Pain Relief: How Menthol Can Help To Soothe Pain

How menthol eases pain by cooling the skin, what studies show about menthol for carpal tunnel pain and sore muscles, and how to use menthol products safely.

Fresh mint leaves in a wooden spoon on a rustic wooden table
  1. Why Use Menthol Instead of Other Treatments?
  2. How Does Menthol Work?
  3. Is Menthol Effective?
  4. Is Menthol Safe?
  5. Frequently asked questions
  6. Sources

Key Takeaways

  • Menthol soothes pain by activating cold-sensing receptors in the skin called TRPM8. As a counterirritant, the cooling feeling it creates can mask the feeling of pain.
  • Small clinical trials have found that topical menthol reduced carpal tunnel pain more than a placebo gel and eased sore muscles more than ice, but larger studies are still needed.
  • Topical menthol is not habit forming and acts where it is applied, which is why some people use it instead of frequent oral pain relievers such as ibuprofen or acetaminophen.
  • Use menthol products only as directed. Keep them away from the eyes, mucous membranes and broken skin, and don't use them with heating pads or tight bandages.

People who live with pain, whether the pain is chronic or temporary, often seek natural alternatives or supplementary treatments that provide relief. 

Menthol is a very popular natural pain relief ingredient, often incorporated into topical balms and gels meant to be applied directly to the source of the pain. 

People turn to menthol because it works well. It’s safe, effective, and can be used as directed on the label to provide quick relief to nagging aches and pains. 

Evidence for the efficacy of menthol comes from a small number of clinical studies, and larger trials are still needed. 

Why Use Menthol Instead of Other Treatments?

Many people dealing with pain that lasts longer than a few days are hesitant to use strong prescription pain medications. 

These pain medications can be sedating and habit forming, even when used over a short period of time. They aren’t intended to be used for the management of chronic pain and should be discontinued after the acute phase of pain has passed.

There are also over-the-counter pain medications, like ibuprofen and acetaminophen. These pain medications are recognized as safe in limited amounts, but long-term or frequent use can cause serious side effects. Ibuprofen can cause damage to the stomach, and acetaminophen can cause damage to the liver. 

While these medications may be valuable for occasional breakthrough pain, daily reliance on these medications is unwise. Swapping relief for side effects that can cause additional pain isn’t sustainable. Always follow the directions on the packaging before using over-the-counter pain relievers. 

This is where menthol becomes a perfect solution. It doesn’t have any addictive potential, it won’t damage the inside of your body when applied topically, and it can be reapplied as directed on the label. Its effects can last several hours. 

Once the menthol has completely worn away, more menthol can be applied if desired.

How Does Menthol Work?

There are receptors all over your skin that are sensitive to the sensation of cold. When they’re activated, they make the surrounding area feel colder than it actually is. 

Menthol is known as a counter-irritant. The pain creates an irritating sensation, and so does the menthol. In response, the irritation from the menthol counterbalances the irritation from the discomfort. The two meet in the middle, and the sensation of the menthol becomes the dominant feeling. 

As the menthol wears off, many people notice that their pain has naturally reduced. 

Is Menthol Effective?

Menthol has been studied for its potential relief benefits for several types of pain. 

One small study testing the effects of menthol against the effects of placebo on the hands of working men with carpal tunnel syndrome found that participants experienced greater relief with menthol. 

The workers were divided into two groups. Half of the participants received a gel prepared with real menthol, while the other half received a gel made with menthol fragrance. At the halfway point, the groups switched. The group receiving the menthol-based treatment reported a greater drop in arm and hand pain than with the placebo.

A sports medicine study compared the effects of ice and menthol on pain and soreness relating to workouts that targeted the elbow flexor. Participants were evaluated for pain 20 minutes after receiving ice or menthol gel. The participants who received menthol gel reported more significant relief.

Patients who used menthol had more than double the amount of tetanic force when using their elbow flexor than the patients who used ice. Tetanic force refers to the ability to sustain a purposeful muscle contraction. In short, the ability to use the affected muscle was greater among the group who received menthol.

This doesn’t necessarily indicate that the menthol resolved the source of the pain, but that the menthol removed some of the inhibitions naturally caused by the pain. Participants felt enough relief to flex their muscles without excessive discomfort. 

While these studies provide a starting point for menthol research, larger studies are still needed. Researchers at Sloan Kettering have also studied menthol as a pain reliever and the channels by which it works. 

Is Menthol Safe?

Menthol is an oil that naturally occurs in mint plants. It’s often used to flavor toothpaste and gum. Most people encounter some form of menthol or mint extracts in their daily lives, and the general verdict is that menthol is suitable for most people.

Menthol is safe and unlikely to cause side effects when used as directed. Menthol should only be applied externally at appropriate concentrations. It shouldn’t be applied to mucous membranes, on broken skin, or anywhere near the eyes. It should only be applied at the approximated source of the pain. 

Take note that it’s possible to have too much of a good thing. Menthol is very potent and produces significant effects, even in small concentrations. Don’t use pure menthol on your skin. The menthol in pain relief products has been properly diluted for safety. 

Pure menthol is exceedingly strong and may act as an irritant. Keep that in mind when the label of a product lists the menthol concentration as a single-digit number. That’s exactly what you want to see, and it means the product will be gentler on the skin. 

Menthol products shouldn’t be applied to skin that is hot to the touch. If you’ve just taken a hot bath or used a heating pad, wait for your skin to dry and rest at room temperature. 

The cooling sensation of the menthol may be too intense when your skin perceives real heat, and the heat opens your pores. This can cause rapid absorption of menthol, making the sensation overwhelming. 

Side effects can include skin irritation, and serious burns have been reported in rare cases. People with an allergy to menthol obviously should not use products formulated with menthol. Most doctors will promote the use of similar topicals to their patients. 

Frequently asked questions

Is menthol or lidocaine better for pain?

Neither is better for everyone, because they work in different ways. Menthol is a counterirritant: it makes the skin feel cold, and that sensation might block pain signals. Lidocaine is a topical anesthetic that numbs the skin to reduce pain. Whichever you use, follow the label, and don't apply it under a heating pad or bandage.

What percentage of menthol is in pain relief creams?

Most over-the-counter menthol pain relievers contain about 5% to 16% menthol, according to a 2022 review. At low to moderate levels, menthol creates a cooling feeling. At higher doses it can cause burning, irritation and pain. In an FDA review of rare serious burns, most second- and third-degree burns involved products with more than 3% menthol, alone or with methyl salicylate.

What should you do if a menthol cream burns your skin?

Stop using the product and get medical care right away if your skin becomes painful, swollen or blistered where you applied it. The FDA reports that rare serious burns, some needing hospital care, have happened with over-the-counter muscle and joint pain relievers that contain menthol. Many happened after a single use, within 24 hours. To lower the risk, don't apply these products to damaged or irritated skin, and don't cover the area tightly or add heat.

Does menthol help arthritis pain?

It may help some people, but the evidence is limited. Mayo Clinic lists menthol among the counterirritants in topical arthritis treatments, which make the skin feel hot or cold and might block pain signals. A 2022 review notes that few menthol products have completed clinical trials, and one knee osteoarthritis study found no difference in pain or function. Ask your doctor which treatments fit your type of arthritis.

Sources & references

  1. Li Z, Zhang H, Wang Y, et al.. “The distinctive role of menthol in pain and analgesia: Mechanisms, practices, and advances.” Frontiers in Molecular Neuroscience, 2022. frontiersin.org
  2. Sundstrup E, Jakobsen MD, Brandt M, et al.. “Acute Effect of Topical Menthol on Chronic Pain in Slaughterhouse Workers with Carpal Tunnel Syndrome: Triple-Blind, Randomized Placebo-Controlled Trial.” Rehabilitation Research and Practice, 2014. doaj.org
  3. Johar P, Grover V, Topp R, Behm DG. “A Comparison of Topical Menthol to Ice on Pain, Evoked Tetanic and Voluntary Force During Delayed Onset Muscle Soreness.” International Journal of Sports Physical Therapy, 2012. epublications.marquette.edu
  4. Mayo Clinic Staff. “Arthritis pain: Treatments absorbed through your skin.” Mayo Clinic, 2025. mayoclinic.org
  5. U.S. Food and Drug Administration. “FDA Drug Safety Communication: Rare cases of serious burns with the use of over-the-counter topical muscle and joint pain relievers.” U.S. Food and Drug Administration, 2012. fda.gov
  6. MedlinePlus. “Ibuprofen: MedlinePlus Drug Information.” MedlinePlus, U.S. National Library of Medicine, 2023. medlineplus.gov
  7. Mayo Clinic Staff. “Acute liver failure: Symptoms and causes.” Mayo Clinic, 2024. mayoclinic.org

Staff Writer

The Hempvana editorial team writes practical, source-backed guides on everyday pain relief, topical ingredients and healthy movement.

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